Distribution and ecological risks of pharmaceuticals and personal care products with different anthropogenic stresses in a coastal watershed of China.

The occurrences of pharmaceutical and personal care products (PPCPs) in both freshwater and sea have been widely reported. However, pollution control requires further information on riverine discharges with influence of land-based activities and associated risks to estuarine ecosystems. This study investigated the spatial occurrences and the relationship to sociodemographic parameters of 30 PPCPs in 67 rivers along the Bohai coastal region. The results showed that PPCPs were mainly deposited in aquatic phase, and the partitioning coefficient between water and sediment was highly determined by chemical properties. The levels of 30 PPCPs in rivers ranged from 8.33 to 894.48 ng/L, showing a large variance among regions. Caffeine, sulfamethoxazole, sulfamethazine, ofloxacin, anhydro-erythromycin, and trimethoprim were found to be the major pollutants. Multivariable analysis method was used to assess the correlation of PPCPs markers to socio-economic parameters. The results indicated that domestic emissions contributed most to the occurrences of PPCPs in the riverine water. Risk assessment result indicated that sulfamethoxazole, caffeine, tetracycline, and carbamazepine ranked top four with the highest risks to the most sensitive aquatic organisms. The results identified caffeine and carbamazepine with high detection frequency and concentration as the priority chemicals, while sulfamethoxazole and erythromycin should also be concerned due to their potential threats in specific rivers. This study provides valuable information for pollution control over PPCPs riverine discharges in estuarine regions. [Display omitted] • Riverine input significantly contributed to PPCPs in the estuarine region. • Correlation between Kow and Kd was found for macrolides in sediment. • Multivariable statistical analysis identified PPCPs markers with different activities. • Domestic emission from major cities was dominant in estuarine discharges of PPCPs. • Sulfamethoxazole and caffeine posed threats to the most sensitive aquatic species. [ABSTRACT FROM AUTHOR]