Rapid and sustained effects of dupilumab in severe chronic rhinosinusitis with nasal polyps.

Onset of treatment effect with dupilumab was similar regardless of prior surgery, asthma, NSAID-ERD, or AR (Supplementary Figures S1-S4). Onset of symptom improvement was similar in patients with prior sinonasal surgery, asthma, NSAID-ERD, and AR, who may have more severe disease and be more difficult to treat. The onset of action, magnitude, and maintenance of treatment effect were similar regardless of prior surgery, or comorbid asthma, NSAID-ERD, or AR. [Extracted from the article]