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Chromium-catalyzed couplings of C(aryl)–SMe bonds for accessing arylated and alkylated benzaldehyde derivatives.
- Source :
-
Chemical Communications . 6/25/2022, Vol. 58 Issue 50, p7094-7097. 4p. - Publication Year :
- 2022
-
Abstract
- Described here is the chromium-catalyzed cleavage of C(aryl)–SMe bonds leading to coupling with organomagnesium to give functionalized benzaldehydes under mild conditions. This reaction was promoted specifically by a low-cost and simple CrCl2 salt used as a precatalyst, enabling synchronous activations of ortho-C(aryl)–SMe and ortho′-C(aryl)–H bonds to achieve difunctionalization of benzaldimines. This work provided a strategy for accessing arylated, alkylated, and diarylated benzaldehyde derivatives as a result of the couplings of C(aryl)–SMe and C(aryl)–SMe/C(aryl)–H bonds promoted with cost-effective Cr catalysis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CATALYSIS
*BENZALDEHYDE
*SALT
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 58
- Issue :
- 50
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 157547609
- Full Text :
- https://doi.org/10.1039/d2cc01631a