Allylations of aryl/heteroaryl ketones: neat, clean, and sustainable. Applications to targets in the pharma- and nutraceutical industries.

Aromatic and heteroaromatic ketones bearing an α-methine proton can be deprotonated and mono-allylated in minutes in the complete absence of an organic solvent to arrive at the corresponding products in high isolated yields. Applications to synthetic targets including both MK-7 and MK-9, as well as coenzyme Q9 (CoQ9), utilizing this new technology are documented. [ABSTRACT FROM AUTHOR]