抗病毒治疗适应证变化对提高慢性乙型肝炎治疗率的影响.

Objective To investigate the impact of the change in anti - hepatitis B virus ( HBV) therapy indication on treatment rate and the features of the population requiring treatment. Methods The treatment - nfilve patients with chronic hepatitis B ( CHB ) in the China Registry of Hepatitis B (CR - HepB) database were selected as subjects, and related demographic, virological, hematological, and biochemical data were collected. The Mann - Whitney U test was used for comparison of non - normally distributed continuous data between two groups, and the Kruskal - Wallis H test was used for comparison between multiple groups; the chi - square test or the Fisher ' s exact test was used for comparison of categorical data between groups. Results A total of 3640 treatment - nafve CHB patients were included in this study, among whom 64. 4% were male, 68 . 7% had an age of 30 - 59 years, and 46 . 8% had an indeterminate clinical stage. According to the 2015 and 2019 editions of Guidelines for the prevention and treatment of chronic hepatitis Band the 2022 edition of expert consensus, the number of patients who had the indication for antiviral therapy was 625 ( 17 . 2% ), 1333 ( 36. 6% ), and 2890 ( 79 . 4% ), respectively. The number of patients requiring treatment was increased by 1557 according to the 2022 edition of expert consensus, among whom 1424 ( 91. 5 % ) met the treatment threshold of alanine aminotransferase ( ALT) > 30 U/ L for male patients or ALT > 19 U/ L for female patients. The additional patients requiring treatment according to the 2022 edition of expe rt consensus had significantly higher levels of ALT and HBV DNA and significantly lower scores of APRI and FIB -4 than the additional patients requiring treatment according to the 2019 edition of Guidelines (all P <0. 05). Conclusion The expansion of antiviral therapy indications for CHB may significantly increase the proportion of CHB patients receiving antiviral treatment and help mild CHB patients at the risk of disease progression to receive timely treatment and achieve the improvement in long - term prognosis. [ABSTRACT FROM AUTHOR]