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Anthocyanin-Rich Blackcurrant Extract Preserves Gastrointestinal Barrier Permeability and Reduces Enterocyte Damage but Has No Effect on Microbial Translocation and Inflammation After Exertional Heat Stress.
- Source :
-
International Journal of Sport Nutrition & Exercise Metabolism . Jul2022, Vol. 32 Issue 4, p265-274. 10p. 1 Chart, 4 Graphs. - Publication Year :
- 2022
-
Abstract
- This study investigated the effects of 7 days of 600 mg/day anthocyanin-rich blackcurrant extract intake on small intestinal permeability, enterocyte damage, microbial translocation, and inflammation following exertional heat stress. Twelve recreationally active men (maximal aerobic capacity = 55.6 ± 6.0 ml·kg−1·min−1) ran (70% VO2max) for 60 min in an environmental chamber (34 °C, 40% relative humidity) on two occasions (placebo/blackcurrant, randomized double-blind crossover). Permeability was assessed from a 4-hr urinary excretion of lactulose and rhamnose and expressed as a ratio of lactulose/rhamnose. Venous blood samples were taken at rest and 20, 60, and 240 min after exercise to measure enterocyte damage (intestinal fatty acid-binding protein); microbial translocation (soluble CD14, lipopolysaccharide-binding protein); and interleukins 6, interleukins 10, and interleukins 1 receptor antagonist. Exercise increased rectal temperature (by ∼2.8 °C) and heart rate (by ∼123 beats/min) in each condition. Blackcurrant supplementation led to a ∼12% reduction in lactulose/rhamnose ratio (p <.0034) and enterocyte damage (∼40% reduction in intestinal fatty acid-binding protein area under the curve; p <.0001) relative to placebo. No between-condition differences were observed immediately after exercise for lipopolysaccharide-binding protein (mean, 95% confidence interval [CI]; +80%, 95% CI [+61%, +99%]); soluble CD14 (+37%, 95% CI [+22%, +51%]); interleukins 6 (+494%, 95% CI [+394%, +690%]); interleukins 10 (+288%, 95% CI [+105%, +470%]); or interleukins 1 receptor antagonist (+47%, 95% CI [+13%, +80%]; all time main effects). No between-condition differences for these markers were observed after 60 or 240 min of recovery. Blackcurrant extract preserves the GI barrier; however, at subclinical levels, this had no effect on microbial translocation and downstream inflammatory processes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LIPOPOLYSACCHARIDES
*INTERLEUKINS
*FLAVONOIDS
*CONFIDENCE intervals
*PHYSIOLOGICAL effects of heat
*INFLAMMATION
*PERMEABILITY
*FATTY acid-binding proteins
*BLOOD collection
*TREATMENT effectiveness
*DIETARY supplements
*RANDOMIZED controlled trials
*SMALL intestine
*DESCRIPTIVE statistics
*BLIND experiment
*PLANT extracts
*EPITHELIAL cells
*STATISTICAL sampling
*CROSSOVER trials
*DEOXY sugars
*DISACCHARIDES
*EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 1526484X
- Volume :
- 32
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- International Journal of Sport Nutrition & Exercise Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 157688012
- Full Text :
- https://doi.org/10.1123/ijsnem.2021-0330