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The Antisenescence Effect of Exosomes from Human Adipose-Derived Stem Cells on Skin Fibroblasts.
- Source :
-
BioMed Research International . 6/29/2022, p1-12. 12p. - Publication Year :
- 2022
-
Abstract
- Human adipose-derived stem cells (ADSCs) have become a promising therapeutic approach against skin aging. Recent studies confirm that exosomes partially mediate the therapeutic effect of stem cells. This study successfully isolated exosomes from the ADSC culture medium and discovered that ADSC-derived exosomes (ADSC-Exos) could alleviate human dermal fibroblast (HDF) senescence and stimulate HDF migration. Moreover, ADSC-Exos increased the type I collagen expression level and reduced the reactive oxygen species (ROS) and senescence-associated β-galactosidase (SA-β-Gal) activity in HDFs. In addition, we demonstrated that ADSC-Exos significantly inhibited senescence-related protein expression levels of p53, p21, and p16. In conclusion, our results have revealed the antisenescence effects of ADSC-Exos on HDFs and ADSC-Exos may be a novel cell-free therapeutic tool for antiaging. [ABSTRACT FROM AUTHOR]
- Subjects :
- *EXOSOMES
*FIBROBLASTS
*CELL migration
*CULTURE media (Biology)
*MICROBIOLOGICAL assay
*WESTERN immunoblotting
*HEALTH outcome assessment
*GENE expression
*T-test (Statistics)
*STEM cells
*SKIN aging
*GLYCOSIDASES
*CELL proliferation
*DESCRIPTIVE statistics
*REACTIVE oxygen species
*DATA analysis software
*ADIPOSE tissues
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Database :
- Academic Search Index
- Journal :
- BioMed Research International
- Publication Type :
- Academic Journal
- Accession number :
- 157708912
- Full Text :
- https://doi.org/10.1155/2022/1034316