Network pharmacology and metabolomics-based detection of the potential pharmacological effects of the active components in Chrysanthemum morifolium 'Chuju'.

Chrysanthemum morifolium ‗Chuju' is a famous medicinal species in traditional Chinese medicine. ‗Chuju' contains various active ingredients that can be used to treat multiple diseases without toxic side effects. In the present study, we combined metabolomics and network pharmacology to further explore the active ingredients in ‗Chuju', as well as the target and pharmacological mechanisms of the active ingredients. A visualized network analysis model based on chemistry, pharmacokinetics, and pharmacology was constructed to predict the potential pharmacological mechanism of ‗Chuju'. A total of 424 metabolites of ‗Chuju' were identified, of which 21 ingredients had positive pharmacological effects after ADME screening. The network pharmacology revealed that acacetin and beta-sitosterol in ‗Chuju' could act on GSK3B, MAPK14, ADRA1R, and NOS2 to regulate diabetes mellitus, Alzheimer's disease, breast cancer, and inflammatory diseases. These results indicated the potential pharmacological effects of the active components in ‗Chuju'. [ABSTRACT FROM AUTHOR]