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Synthesis of unsymmetrical 1,3-substituted-1,3-dihydro-benzimidazolones via copper-catalyzed C–N coupling under visible light.
- Source :
-
New Journal of Chemistry . 7/14/2022, Vol. 46 Issue 26, p12465-12469. 5p. - Publication Year :
- 2022
-
Abstract
- Although photoinduced copper catalysis for carbon–nitrogen (C–N) amine bond formation with alkyl/aryl halides has been developed, the potential of copper catalysis for the synthesis of 1,3-substituted benzimidazolone molecules remains mostly unexplored. We herein report for the first time that unsymmetrical 1,3-substituted-1,3-dihydro-benzimidazolones can be readily prepared from monosubstituted benzimidazolones with primary alkyl, allyl, and benzyl bromides in the presence of a catalytic amount of copper(I) bromide and visible light. The catalytic system was optimized and a library of benzimidazolone products were converted in overall great yields up to 99%, demonstrating the utility of this approach for practical and green synthesis schemes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *VISIBLE spectra
*BENZYL bromide
*ARYL halides
*COPPER
*CATALYSIS
Subjects
Details
- Language :
- English
- ISSN :
- 11440546
- Volume :
- 46
- Issue :
- 26
- Database :
- Academic Search Index
- Journal :
- New Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 157813122
- Full Text :
- https://doi.org/10.1039/d2nj02054h