注射罗格列酮对多发性骨髓瘤小鼠细胞免疫功能 与Caspase-3 表达的影响.

Objective: To investigate the effect of rosiglitazone injection on cellular immune function and Caspase-3 expression in mice with multiple myeloma. Methods: Multiple myeloma mice were randomly divided into three groups-model group, red blood cell group and rosiglitazone group. The red blood cell group and rosiglitazone group were given tail vein injection of recombinant mouse erythropoietin 5.0 mg/kg and rosiglitazone 5 mg/kg 100 μL, the model group were given equal volume of normal saline via tail vein injection, once a day, the cellular immune function and Caspase-3 expression changes were detected. Results: The tumor volume on the 7th and 14th day of treatment in the three groups were higher than that on the 1st day of treatment (P<0.05), the red blood cell group and rosiglitazone group were lower than the model group(P<0.05), and the rosiglitazone group were lower than the red blood cell group (P<0. 05). The serum levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-琢in the red blood cell group and rosiglitazone group on the 7th and 14th day of treatment were lower than those of the model group (P<0.05), the rosiglitazone group were lower than the red blood cell group (P<0.05). The ratio of splenic B lymphocytes and T lymphocytes on the 14th day and 28th day of treatment between the red blood cell group and the rosiglitazone group were higher than that of the model group (P<0.05), and the rosiglitazone group were higher than the red blood cell group (P<0.05). The expression of Caspase-3 protein in the substantia nigra of the erythrocyte group and rosiglitazone group were lower on the 14th and 28th day of treatment than the model group (P<0.05), and the rosiglitazone group were lower than that of the red blood cell group (P<0.05). Conclusion: The application of rosiglitazone injection in multiple myeloma mice can improve cellular immune function and inhibit the expression of Caspase-3 in the substantia nigra of the brain. At the same time, it can also promote the weight recovery of mice and inhibit the expression of inflammatory factors. [ABSTRACT FROM AUTHOR]