术前CA125、OPN、CXCL8、NLR 联合检测对乳腺癌改良根治术患者术后 复发转移风险的评估价值.

Objective: To evaluate the value of preoperative detection of carbohydrate antigen 125 (CA125), osteopontin (OPN), chemokine ligand 8 (CXCL8) and neutrophil lymphocyte ratio (NLR) in evaluating recurrence and metastasis risk of breast cancer patients undergoing modified radical mastectomy. Methods: 384 patients with modified radical mastectomy whow ere treated in our hospital from April 2015 to April 2016 were divided into non recurrent metastasis group (n=345) and recurrent metastasis group(n=39) according to postoperative recurrence and metastasis. Compared with CA125, OPN, CXCL8 and NLR in relapse metastasis group and non recurrence metastasis group, multivariate regression analysis was used to analyze the influencing factors of recurrence and metastasis after modified radical mastectomy. The receiver operating characteristic (ROC) curve was used to determine the value of CA125, OPN, CXCL8 and NLR in evaluating the recurrence and metastasis risk of breast cancer patients undergoing modified radical mastectomy. Results: The levels of CA125, OPN, CXCL8 and NLR in recurrence and metastasis group were higher than those in non recurrence and metastasis group(P<0.05). Postoperative recurrence and metastasis of modified radical mastectomy were related to tumor diameter, clinical stage, preoperative neoadjuvant chemotherapy, human epidermal growth factor receptor 2 (HER2), lymph node metastasis, histological type, cell proliferation marker antigen (Ki-67), estrogen receptor(ER) / progesterone receptor (PR), P53, postoperative radiotherapy, postoperative endocrine therapy (P<0.05). Multivariate Logistic regression analysis showed that OPN was high, CXCL8 was high, NLR was high, tumor diameter was greater than 2 cm, lymph node metastasis was positive, ER/PR was double negative, clinical stage was III stage, and preoperative neoadjuvant chemotherapy was not a risk factor for recurrence and metastasis of breast cancer after modified radical mastectomy (P<0.05). The area under the curve (AUC) of preoperative CA125, OPN, CXCL8 and NLR was 0.855, which was higher than that of each index. Conclusion: The recurrence and metastasis of breast cancer after modified radical mastectomy are related to OPN, CXCL8, NLR, tumor diameter, lymph node metastasis, ER/PR, clinical stage and preoperative neoadjuvant chemotherapy. The combined detection of CA125, OPN, CXCL8 and NLR before operation is of high value in evaluating postoperative recurrence and metastasis. [ABSTRACT FROM AUTHOR]