RDW 联合血清 CRP、PCT、sTLT-1 与急性脑梗死患者脑梗死体积、 神经功能受损程度和预后的关系研究.

To observe the relationship between red blood cell distribution width (RDW) combined with serum C-reactive protein (CRP), procalcitonin (PCT), soluble bone marrow cell like transcription factor-1 (sTLT-1) and cerebral infarction volume, neurological impairment and prognosis in patients with acute cerebral infarction (ACI). 100 patients with ACI who were treated in our hospital from April 2019 to October 2021 were selected as the research object. 100 patients were divided into mild to moderate injury group (61 cases, NIHSS ≤ 8 scores) and severe injury group (39 cases, NIHSS > 8 scores) according to the National Institutes of Health Stroke Scale (NIHSS), small focal infarction group (41 cases, infarct volume < 5 cm³ ), medium focal infarction group (35 cases, 5 cm³ ≤ infarct volume ≤ 15 cm³ ) and large focal infarction group (24 cases, infarct volume > 15 cm3 ) according to different volume of cerebral infarction. poor prognosis group (31 cases, mRS ≥ 3 scores) and good prognosis group (69 cases, mRS < 3 scores) according to the modified Rankin Scale (mRS) at discharge. The RDW and the serum CRP, PCT and sTLT-1 levels with different cerebral infarction volume, different NIHSS score and different prognosis in patients with ACI were compared. The influencing factors of poor prognosis in patients with ACI were analyzed by univariate and multivariate Logistic regression. RDW, serum CRP, PCT and stlt-1 increased in turn of patients in small focal infarction group, medium focal infarction group and large focal infarction group, and the difference between the groups was statistically significant ( P<0.05). The RDW and serum CRP, PCT, sTLT-1 levels in severe injury group were higher than those in mild to moderate injury group (P<0.05). The RDW and serum CRP, PCT, sTLT-1 levels in the poor prognosis group were higher than those in the good prognosis group ( P<0.05). There were significant differences in classification of cerebral infarction, smoking history, gender, NIHSS score at admission, age, infarct volume and drinking history between the good prognosis group and the poor prognosis group ( P<0.05). Multivariate Logistic regression analysis showed that higher NIHSS score at admission, larger cerebral infarction volume, complete anterior circulation cerebral infarction, higher RDW, higher CRP, higher PCT and higher sTT-1 were the risk factors for poor prognosis of patients with ACI ( P<0.05). RDW and the serum CRP, PCT, sTLT-1 levels can effectively reflect the cerebral infarction volume and the degree of neurological impairment in patients with ACI, and the prognosis of patients with ACI is affected by NIHSS score, cerebral infarction volume, cerebral infarction classification, RDW, CRP, PCT, sTLT-1 and other factors. [ABSTRACT FROM AUTHOR]