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Ketoconazole increases atovaquone exposure following concomitant administration with Malarone® in healthy subjects.
- Source :
-
Journal of Travel Medicine . May2022, Vol. 29 Issue 4, p1-4. 4p. - Publication Year :
- 2022
-
Abstract
- With an aim to assess the pharmacokinetics of atovaquone, 10 healthy subjects were administered Malarone® alone and in combination with ketoconazole in a crossover study. The results indicated 68% higher Cmax, 74% higher AUC and 34% lower CL/F of atovaquone following co-administration with ketoconazole compared to administration of atovaquone alone. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11951982
- Volume :
- 29
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Travel Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 158041453
- Full Text :
- https://doi.org/10.1093/jtm/taac058