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Patient outcomes following AKI and AKD: a population-based cohort study.
- Source :
-
BMC Medicine . 7/19/2022, Vol. 20 Issue 1, p1-17. 17p. - Publication Year :
- 2022
-
Abstract
- <bold>Background: </bold>Acute kidney injury (AKI) is common and associated with adverse outcomes as well as important healthcare costs. However, evidence examining the epidemiology of acute kidney disease (AKD)-recently defined as AKI persisting between 7 and 90 days-remains limited. The aims of this study were to establish the rates of early AKI recovery, progression to AKD and non-recovery; examine risk factors associated with non-recovery and investigate the association between recovery timing and adverse outcomes, in a population-based cohort.<bold>Methods: </bold>All adult residents of Tayside & Fife, Scotland, UK, with at least one episode of community or hospital-managed AKI using KDIGO creatinine-based definition during the period 1 January 2010 to 31 December 2018 were identified. Logistic regression was used to examine factors associated with non-recovery, and Cox modelling was used to establish associations between AKI recovery timing and risks of mortality and development of de novo CKD.<bold>Results: </bold>Over 9 years, 56,906 patients with at least one AKI episode were identified with 18,773 (33%) of these progressing to AKD. Of those progressing to AKD, 5059 (27%) had still not recovered at day 90 post AKI diagnosis. Risk factors for AKD included: increasing AKI severity, pre-existing cancer or chronic heart failure and recent use of loop diuretics. Compared with early AKI recovery, progression to AKD was associated with increased hazard of 1-year mortality and de novo CKD (HR = 1.20, 95% CI 1.13 to 1.26 and HR = 2.21, 95% CI 1.91 to 2.57 respectively).<bold>Conclusions: </bold>These findings highlight the importance of early AKI recognition and management to avoid progression to AKD and long-term adverse outcomes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17417015
- Volume :
- 20
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- BMC Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 158079027
- Full Text :
- https://doi.org/10.1186/s12916-022-02428-8