哺乳动物卵泡相关代谢组学研究进展.

The oocyte quality is one of the determining factors of successful assisted reproductive technology (ART) outcome. It is beneficial to establish a simple and reliable evaluation system of oocyte quality for improving the success rate of ART. Newly developed metabolomics is expected to provide a new method for evaluating oocyte quality. At present, metabolomics has been used in many relevant studies of female reproduction. By the qualitative and quantitative analysis of small and medium-sized molecules in oocytes, granulosa cells and follicular fluid samples, researchers have identified a variety of symbolic metabolites related to female infertility, which are involved in the metabolism of carbohydrate, lipid, amino acid and other substances. These studies have showed the potential application of metabolomics in the diagnosis and treatment of infertility. We review the research progress in the metabolomics of mammalian follicles. [ABSTRACT FROM AUTHOR]