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Effect of Vaccination against Leptospira on Shelter Asymptomatic Dogs Following a Long-Term Study.
- Source :
-
Animals (2076-2615) . Jul2022, Vol. 12 Issue 14, p1788-N.PAG. 10p. - Publication Year :
- 2022
-
Abstract
- Simple Summary: Dogs are known as hosts of Leptospira interrogans and can become asymptomatic carriers of leptospires in the urine, spreading this bacterium to the environment, especially in endemic areas, characterizing a serious public health problem. In this context, vaccination of dogs against leptospirosis is of paramount importance for long-term protection against renal carrier status. A total of 118 dogs were studied for 365 days, separated into Group A (vaccinated, n = 94) and Group B (non-vaccinated, n = 24). Group A was subdivided into three groups: A1 with 32 dogs immunized with the vaccine #1; A2 by 32 dogs with #2; and A3 30 dogs with #3. Serology (MAT and IgG-ELISA) and urinary PCR were conducted. Seroreactivity increased at D15 post-vaccination and, regardless of vaccine brand, remained high up to D180, with antibody switch to IgG after D30. A total of 46.8% of animals from Group A were PCR-positive at least once, in contrast to 75% in Group B, regardless of vaccine brand. (1) Background: Vaccination of dogs against leptospirosis is of paramount importance, as they ideally must provide not only long-term protection, but also against the renal carrier state of leptospires. This study assessed the post-vaccine humoral response against Leptospira in naturally exposed dogs and effects on renal carrier status. (2) Methods: A total of 118 dogs were studied for 365 days, separated into Group A (vaccinated, n = 94) and Group B (non-vaccinated, n = 24). Group A was subdivided into three groups: A1 with 32 dogs immunized with the vaccine #1; A2 by 32 dogs with #2; and A3 30 dogs with #3. Serology (MAT and IgG-ELISA) and urinary PCR were conducted. (3) Results: Seroreactivity increased at D15 post-vaccination and, regardless of vaccine brand, remained high up to D180, with antibody switch to IgG after D30. A total of 46.8% of animals from Group A were PCR-positive at least once, in contrast to 75% in Group B, regardless of vaccine brand (p < 0.05; OR: 0.3). (4) Conclusions: All commercial vaccines succeeded at eliciting a long-term IgG-based response and were partially effective at protecting against kidney infection. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20762615
- Volume :
- 12
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- Animals (2076-2615)
- Publication Type :
- Academic Journal
- Accession number :
- 158177054
- Full Text :
- https://doi.org/10.3390/ani12141788