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Update on the Classification of and Diagnostic Approaches to Mature T-Cell Lymphomas.
- Source :
-
Archives of Pathology & Laboratory Medicine . Aug2022, Vol. 146 Issue 8, p947-952. 6p. 1 Diagram, 2 Charts. - Publication Year :
- 2022
-
Abstract
- Context.--In the 2017 revised World Health Organization classification of tumors of hematopoietic and lymphoid tissues, some mature T-cell lymphomas were reclassified and a few new provisional entities were established based on new data from clinical and laboratory studies. T follicular helper cell lymphoma is identified by T follicular helper cell markers. Anaplastic large cell lymphoma, ALK negative, is a better-defined entity based on genetic abnormalities, and breast implant--associated anaplastic large cell lymphoma is recognized as a provisional entity. The gastrointestinal T-cell lymphomas are reclassified, with addition of a new provisional entity, indolent T-cell lymphoproliferative disorder of the gastrointestinal tract, characterized by an indolent clinical course. Objective.--To review the diagnostic approaches to reclassified and newly established entities of mature T-cell lymphomas, focusing on significant immunophenotypic features and molecular genetic abnormalities. Relevant new discoveries after the publication of the 2017 World Health Organization classification are included. Data Sources.--Information from the literature most relevant to the 2017 World Health Organization revised classification and publications after 2016. Conclusions.--Incorporating clinical, morphologic, and immunophenotypic features usually provides sufficient evidence to reach a preliminary diagnosis of mature T-cell lymphoma. Molecular genetic studies can be very helpful for the final diagnosis and classification, especially in challenging cases. Some molecular genetic features have been found in breast implant--associated anaplastic large cell lymphoma, distinct from anaplastic large cell lymphoma, ALK negative. Immunohistochemical staining of 4 markers may enable further subtyping of peripheral T-cell lymphomas. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00039985
- Volume :
- 146
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Archives of Pathology & Laboratory Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 158224773
- Full Text :
- https://doi.org/10.5858/arpa.2021-0143-RA