Sophoridine Inhibits Breast Cancer Cell Migration and Angiogenesis by Regulating Vascular Endothelial Growth Factor Receptor 2/Extracellular Signal-Regulated Kinase 2 Pathways.

Breast cancer is the most common form of cancer in women in need for better treatment. Sophoridine, a plant-derived quinoxidine alkaloid, has been shown to exhibit pharmacological effects on several diseases including lung and gastric cancers. To further extend these beneficial effects we have explored the role of sophoridine in breast cancer progression. Our results show that sophoridine suppressed the proliferation of breast cancer cells and inhibited the migration as well as invasion. In addition, sophoridine inhibited the angiogenesis of breast cancer cells. Mechanically, our data confirmed that sophoridine suppressed the vascular endothelial growth factor receptor 2/extracellular signal-regulated kinase 2 pathway, and therefore suppressed breast cancer progression. We therefore suggest that sophoridine could serve as a promising drug for the treatment of breast cancer. [ABSTRACT FROM AUTHOR]