Back to Search
Start Over
Evaluation of interstitial cells of cajal-like cells at the pelviureteric junction in children with pelviureteric junction obstruction: A prospective study and review of literature.
- Source :
-
Journal of Indian Association of Pediatric Surgeons . Jul/Aug2022, Vol. 27 Issue 4, p395-401. 7p. - Publication Year :
- 2022
-
Abstract
- Introduction: The etiopathogenesis of pelviureteric junction obstruction (PUJO) has been debated. Recently, the role of interstitial cells of Cajal-like cells (ICC-LC) has been studied and reported to be the cause of this functional obstruction. We studied the histopathology and ICC-LC density at PUJ and compared it with that of PUJ of the control group and distal ureteric margin of the study group. Methods: A prospective study was conducted which included PUJO patients in the study group and the renal tumor patients in the control group. Histopathological examination (muscle hypertrophy and fibrosis) and immunohistochemistry (ICC-LC density) were done. The muscle hypertrophy, fibrosis, and ICC-LC density at the PUJ in both the groups were compared. A similar comparison was performed between the findings at the PUJ and the distal margin in the study group. Results: The study and control groups included 37 PUJO patients and 13 Wilms tumor patients. The ICC-LC density at PUJ in the study group was significantly lower than that in the control group (P < 0.001) and that at the distal resected margin of the study group (P < 0.001). Significantly increased muscle hypertrophy (P < 0.001) and fibrosis (P = 0.002) were seen at PUJ in the study group compared to the control group. No significant association was noted between the ICC-LC density and muscle hypertrophy at PUJ and the distal resected margin in the study group. Conclusion: A significant decrease in the density of ICC-LC and increased fibrosis and muscle hypertrophy at PUJ in children with PUJO play a role in the etiopathogenesis of the disease. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09719261
- Volume :
- 27
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Indian Association of Pediatric Surgeons
- Publication Type :
- Academic Journal
- Accession number :
- 158340673
- Full Text :
- https://doi.org/10.4103/jiaps.jiaps_103_21