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High incidence of undetected low sensor glucose events among elderly patients with type 2 diabetes more than a decade on after the ACCORD study.
- Source :
-
Current Medical Research & Opinion . Aug2022, Vol. 38 Issue 8, p1411-1415. 5p. - Publication Year :
- 2022
-
Abstract
- Hypoglycaemia leads to significant morbidity and impacts negatively on quality-of-life, especially in elderly people with increased frailty. The aims of this study were to determine the prevalence of low interstitial fluid glucose (IFG) in patients with tightly controlled type 2 diabetes (T2D), and to evaluate whether there were differences in burden of low IFG between sulphonylurea and insulin treated groups. A Freestyle Libre-Pro sensor was used for sampling of the IFG continuously. Patients were blinded to the IFG levels. The sensor was returned to the investigators after a 2-week period and the data were downloaded for analysis. There was a total of 69 patients (median age 72 years (IQR = 69–74)) − 40 were sulfonylurea-treated and 29 insulin-treated. In total, 781 low sensor glucose events (<4.0 mmol/L) were detected, of which 254 were very low sensor glucose events (<2.8 mmol/L). Twenty-six out of 29 insulin-treated (89.6%) and 36 out of 40 sulphonylurea-treated patients (90%) contributed to the 781 events of low sensor glucose. Twenty out of 29 insulin-treated (69%) and 26 out of 40 sulphonylurea-treated patients (65.0%) contributed to the 254 very low sensor glucose events. Only 9% of all events were identified by patients. Nocturnal events represented 55.8% of low sensor glucose events and 61.0% of very low sensor glucose events. At a cut-off of <2.8 mmol/L, it was found that the insulin group had a significantly greater number of such events as compared to the sulfonylurea group. This study demonstrates that elderly patients with tightly-controlled T2D have a significant number of low sensor glucose events which go by undetected. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INSULIN
*OLDER patients
*TYPE 2 diabetes
*GLUCOSE
*INSULIN aspart
*OLDER people
Subjects
Details
- Language :
- English
- ISSN :
- 03007995
- Volume :
- 38
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Current Medical Research & Opinion
- Publication Type :
- Academic Journal
- Accession number :
- 158361026
- Full Text :
- https://doi.org/10.1080/03007995.2022.2065143