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Three new polyketide derivatives of the endophytic fungus Aspergillus cristatus 2H1.
- Source :
-
Journal of Asian Natural Products Research . Aug2022, Vol. 24 Issue 8, p722-730. 9p. - Publication Year :
- 2022
-
Abstract
- Three new polyketide derivatives, 2-ethoxycarbonyl-endocrocin (1), 6-methoxy-2-ethoxycarbonyl-endocrocin (2) and pannorin C (3), along with sixteen known compounds (4–19) were isolated from a plant endophytic fungus Aspergillus cristatus 2H1. Their structures were elucidated by 1D/2D NMR and HR-ESI-MS data analysis. Compound 3 showed weak antibacterial activity against Staphylococcus aureus (MIC 20 μg/ml). Compounds 14 and 15 showed effective cytotoxicity on human melanoma A375 cells (IC50 4.13 μM for 14, 3.39 μM for 15). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 24
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 158361130
- Full Text :
- https://doi.org/10.1080/10286020.2021.1972982