Microwave-mediated approach to highly substituted nitropyrimidines via double Mannich reactions and their biological properties.

In the current study, new polysubstituted nitropyridimines were efficiently synthesized via double Mannich cyclizations of diaryl substituted β-nitroenamines with formaldehyde and aniline derivatives under microwave irradiation for 30–40 min. Furthermore, an antioxidant study showed that some of the nitropyridimines have moderate to low scavenging activity against DPPH radical. Also, in a preliminary antibacterial activity test of selected products, only one product exhibited moderate antibacterial effect against S.Epidermidis bacteria. To create your abstract, type over the instructions in the template box below.Fonts or abstract dimensions should not be changed or altered. [Display omitted] [ABSTRACT FROM AUTHOR]