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Vitamin C supramolecular hydrogel for enhanced cancer immunotherapy.
- Source :
-
Biomaterials . Aug2022, Vol. 287, pN.PAG-N.PAG. 1p. - Publication Year :
- 2022
-
Abstract
- Vitamin C (VitC) has shown great promise to promote cancer immunotherapy, however, its high hydrophilicity makes it quickly excreted, leading to limited therapeutic efficiency even with frequent high-dose administration. Herein, we provide a pioneering report about the employment of VitC amphiphile self-assembled nanofiber hydrogels for enhanced cancer immunotherapy. Specifically, driven by hydrogen bonding and hydrophobic interactions, the synthesized VitC amphiphile, consisting of a hydrophilic VitC headgroup and a hydrophobic alkyl chain, could self-assemble into an injectable nanofiber hydrogel with self-healing properties. The formed VitC hydrogel not only serves as a reservoir for VitC but also acts as an effective delivery platform for stimulator of interferon genes (STING) agonist-4 (SA). Interestingly, the VitC hydrogel itself exhibits antitumor effects by upregulating genes related to interferon (IFN) signaling, apoptotic signaling and viral recognition and defense. Moreover, the SA-encapsulated VitC hydrogel (SA@VitC hydrogel) synergistically activated the immune system to inhibit the progression of both local and abscopal tumors. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYDROGELS
*HYDROGEN bonding interactions
*IMMUNOTHERAPY
*VITAMIN C
*VITAMINS
Subjects
Details
- Language :
- English
- ISSN :
- 01429612
- Volume :
- 287
- Database :
- Academic Search Index
- Journal :
- Biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 158368622
- Full Text :
- https://doi.org/10.1016/j.biomaterials.2022.121673