The Yin and Yang of Modulating β-Cell DNA Damage Response and Functional Mass.

The article discusses the new insights into the importance of YY1 in controlling b-cell DDR to promote growth, survival, and maturation. Topics include the key finding of this study is the downregulation of YY1 under conditions of b-cell stress, such as those for the db/db mice and T2D donors; Cells like the adult b-cell must deploy robust strategies, such as efficient repair of DNA damage, to ensure their genomic integrity and survival throughout their lifespans.