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Transcranial direct current stimulation does not improve clinical and neurophysiological outcomes in panic disorder: A randomized sham‐controlled trial.

Authors :
Aksu, Serkan
Soyata, Ahmet Zihni
Mursalova, Zhala
Eskicioğlu, Gaye
Tükel, Raşit
Source :
Psychiatry & Clinical Neurosciences. Aug2022, Vol. 76 Issue 8, p384-392. 9p. 1 Diagram, 3 Charts.
Publication Year :
2022

Abstract

Aim: Emerging evidence suggests that transcranial direct current stimulation (tDCS) has anxiolytic effects and may enhance emotional processing of threat and reduce threat‐related attentional bias. Panic disorder (PD) is considered to be a fear network disorder along with prefrontal activity alterations. We aim to assess the effect of tDCS on clinical and physiological parameters in PD for the first time. Methods: In this triple‐blind randomized sham‐controlled pilot study, 30 individuals with PD were allocated into active and sham groups to receive 10 sessions of tDCS targeting the dorsolateral prefrontal cortex bilaterally at 2 mA for 20‐min duration over 2 weeks. The clinical severity, threat‐related attentional bias, interoceptive accuracy, and emotional recognition were assessed before, immediately after, and 1 month after tDCS. Results: Active tDCS, in comparison to sham, did not elicit more favorable clinical and neuropsychological/physiological outcomes in PD. Conclusion: The present study provides the first clinical and neurobehavioral results of prefrontal tDCS in PD and indicates that prefrontal tDCS was not superior to sham in PD. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13231316
Volume :
76
Issue :
8
Database :
Academic Search Index
Journal :
Psychiatry & Clinical Neurosciences
Publication Type :
Academic Journal
Accession number :
158448674
Full Text :
https://doi.org/10.1111/pcn.13378