Relevant sensitization to diethylamino hydroxybenzoyl hexyl benzoate and fragrances in a patient with frontal fibrosing alopecia and acquired dermal macular hyperpigmentation.

Keywords: acquired dermal macular hyperpigmentation; CAS no. 302776-68-7; case report; cinnamal; cinnamyl alcohol; diethylamino hydroxybenzoyl hexyl benzoate; frontal fibrosing alopecia; lichen planus pigmentosus; pigmented contact dermatitis; sunscreens EN acquired dermal macular hyperpigmentation CAS no. 302776-68-7 case report cinnamal cinnamyl alcohol diethylamino hydroxybenzoyl hexyl benzoate frontal fibrosing alopecia lichen planus pigmentosus pigmented contact dermatitis sunscreens 287 289 3 08/16/22 20220901 NES 220901 We report a patient with pruritic hyperpigmentation of the face and neck, who subsequently developed frontal fibrosing alopecia (FFA), and who was shown to be sensitized to fragrances and to the ultraviolet (UV)-filter diethylamino hydroxybenzoyl hexyl benzoate. Co-sensitizations to cinnamal and cinnamyl alcohol have recently been described in patients' photo-allergic to ketoprofen,10 the latter also being a benzophenone derivative, similar to benzophenone-3 (oxybenzone) and diethylamino hydroxybenzoyl hexyl benzoate (Figure S1). Case report, acquired dermal macular hyperpigmentation, CAS no. 302776-68-7, diethylamino hydroxybenzoyl hexyl benzoate, cinnamal, cinnamyl alcohol, frontal fibrosing alopecia, lichen planus pigmentosus, pigmented contact dermatitis, sunscreens. [Extracted from the article]