Association of CYBA C242T and superoxide dismutase 2 A16V genetic variants with preeclampsia.

Objective: To investigate the relationship between NADPH oxidase p22phox subunit (CYBA; C242T) and superoxide dismutase 2 (SOD2; A16V) polymorphisms and the risk of preeclampsia (PE) in Chinese women. Methods: This case‐control study included 325 patients with PE and 1294 controls. The genotypes were determined by polymerase chain reaction‐restriction fragments length polymorphism method. Clinical, metabolic, and oxidative stress parameters were analyzed. Results: Participants with T allele of the CYBA C242T polymorphism had a decreased risk of PE (OR = 0.62, 95% CI: 0.42–0.92, P = 0.016) and those with the A allele of the SOD2 A16V polymorphism had increased risk of PE (OR = 1.44, 95% CI: 1.09–1.89, P = 0.010). The coexistence of the SOD2 AA + AV genotypes and the CYBA CC genotype further increased the risk of PE (OR = 2.32, 95% CI: 1.31–4.10, P = 0.003) when the CT + TT/VV combined genotype was the reference category. Conclusion: The T allele of the CYBA C242T polymorphism is related to a decreased risk of PE, while the A allele of the SOD2 A16V polymorphism and its combination with the CYBA CC genotype are associated with an increased risk of PE in Chinese women. T allele of CYBA C242T polymorphism is a protective factor of PE and A allele of SOD2 A16V polymorphism is a risk factor of PE. [ABSTRACT FROM AUTHOR]