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Mucosal-associated invariant T cells are activated in an interleukin-18-dependent manner in Epstein–Barr virus-associated T/natural killer cell lymphoproliferative diseases.
- Source :
-
Clinical & Experimental Immunology . Feb2022, Vol. 207 Issue 2, p141-148. 8p. - Publication Year :
- 2022
-
Abstract
- Mucosal-associated invariant T (MAIT) cells are a type of innate immune cells that protect against some infections. However, the involvement of MAIT cells in Epstein–Barr virus-associated T/natural killer cell lymphoproliferative diseases (EBV-T/NK-LPD) is unclear. In this study, we found that MAIT cells were highly activated in the blood of patients with EBV-T/NK-LPD. MAIT cell activation levels correlated with disease severity and plasma IL-18 levels. Stimulation of healthy peripheral blood mononuclear cells with EBV resulted in activation of MAIT cells, and this activation level was enhanced by exogenous IL-18. MAIT cells stimulated by IL-18 might thus be involved in the immunopathogenesis of EBV-T/NK-LPD. [ABSTRACT FROM AUTHOR]
- Subjects :
- *KILLER cells
*T cells
*LYMPHOPROLIFERATIVE disorders
*MONONUCLEAR leukocytes
Subjects
Details
- Language :
- English
- ISSN :
- 00099104
- Volume :
- 207
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Clinical & Experimental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 158572319
- Full Text :
- https://doi.org/10.1093/cei/uxab004