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Targeted drug delivery to the retinal pigment epithelium: Untapped therapeutic potential for retinal diseases.
- Source :
-
Drug Discovery Today . Sep2022, Vol. 27 Issue 9, p2497-2509. 13p. - Publication Year :
- 2022
-
Abstract
- • Most retinal diseases underly multifactorial pathomechanisms. • The retinal pigment epithelium (RPE) plays a key part in these pathomechanisms. • Targeted RPE therapy can be used to efficiently treat retinal diseases. • Intravitreal and systemic nanoparticle systems can reach the RPE. • Guidance for the development of RPE-specific nanotherapeutics is provided. The retinal pigment epithelium (RPE) plays a crucial part in sight-threatening diseases. In this review, we shed light on the pivotal implication of the RPE in age-related macular degeneration, diabetic retinopathy and retinopathy of prematurity; and explain why a paradigm shift toward targeted RPE therapy is needed to efficiently fight these retinal diseases. We provide guidance for the development of RPE-specific nanotherapeutics by giving a comprehensive overview of the possibilities and challenges of drug delivery to the RPE and highlight successful nanotherapeutic approaches targeting the RPE. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13596446
- Volume :
- 27
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Drug Discovery Today
- Publication Type :
- Academic Journal
- Accession number :
- 158674077
- Full Text :
- https://doi.org/10.1016/j.drudis.2022.05.024