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Dupilumab efficacy and biomarkers in chronic rhinosinusitis with nasal polyps: Association between dupilumab treatment effect on nasal polyp score and biomarkers of type 2 inflammation in patients with chronic rhinosinusitis with nasal polyps in the phase 3 SINUS‐24 and SINUS‐52 trials

Authors :
Bachert, Claus
Corren, Jonathan
Lee, Stella E.
Zhang, Haixin
Harel, Sivan
Cunoosamy, Danen
Khan, Asif H.
Jacob‐Nara, Juby A.
Siddiqui, Shahid
Nash, Scott
Rowe, Paul J.
Deniz, Yamo
Source :
International Forum of Allergy & Rhinology. Sep2022, Vol. 12 Issue 9, p1191-1195. 5p.
Publication Year :
2022

Abstract

Correlations were interpreted as very weak (0.00-0.19), weak (0.20-0.39), moderate (0.40-0.59), or strong (0.60-0.79).10 RESULTS Baseline characteristics Baseline demographics, disease characteristics, and biomarkers (Supplementary Table 1) were balanced among treatment groups and were consistent with a population with severe CRSwNP. Further research is needed to determine which biomarkers of type 2 inflammation best correlate with disease-specific objective measures of severity and subjective patient-reported outcomes. [Extracted from the article]

Details

Language :
English
ISSN :
20426976
Volume :
12
Issue :
9
Database :
Academic Search Index
Journal :
International Forum of Allergy & Rhinology
Publication Type :
Academic Journal
Accession number :
158791336
Full Text :
https://doi.org/10.1002/alr.22964