Efficient Synthesis of C3‐Alkylated and Alkenylated Indoles via Manganese‐Catalyzed Dehydrogenation.

The catalytic dehydrogenation of alcohols is essential for the sustainable production of valuable products. This provides a new strategy for green organic synthesis in chemical industries. Herein, we describe a manganese‐based catalytic system that enables the efficient synthesis of C3‐alkylated indoles from benzyl alcohols and indoles via the borrowing hydrogen process. Furthermore, dehydrogenative coupling of 2‐arylethanols and indoles yields C3‐alkenylated indoles. Meanwhile, reacting 2‐aminophenethanol instead of indoles can also obtain the corresponding indole products with high selectivity under the same conditions. [ABSTRACT FROM AUTHOR]