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A Ratiometric Photoacoustic Probe with a Reversible Response to Hydrogen Sulfide and Hydroxyl Radicals for Dynamic Imaging of Liver Inflammation.
- Source :
-
Angewandte Chemie International Edition . 9/12/2022, Vol. 61 Issue 37, p1-7. 7p. - Publication Year :
- 2022
-
Abstract
- Reversible imaging probes that allow for the dynamic visualization of the redox cycle between hydroxyl radical (⋅OH) and hydrogen sulfide (H2S) are vital to probe the redox imbalance‐involved pathological process in vivo. Herein, we report a reversible ratiometric photoacoustic (PA) imaging nanoprobe (1‐PAIN) for the real‐time imaging of ⋅OH/H2S redox cycle in vivo. 1‐PAIN displays a low PA ratio between 690 and 825 nm (PA690/PA825), which significantly increases by ≈5‐fold upon oxidation by ⋅OH, and is switched back to the initially low PA690/PA825 value upon reduction by H2S. 1‐PAIN could dynamically report on the hepatic ⋅OH production in mice during the lipopolysaccharide (LPS)‐induced liver inflammation process, and visualize hepatic H2S generation during the N‐acetyl cysteine (NAC)‐induced anti‐inflammation process. 1‐PAIN can act as a useful tool to probe the redox state in living biology, beneficial for the study of redox imbalance‐related diseases. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYDROGEN sulfide
*HEPATITIS
*HYDROXYL group
*ACETYLCYSTEINE
*ACOUSTIC imaging
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 61
- Issue :
- 37
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 158915926
- Full Text :
- https://doi.org/10.1002/anie.202209248