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DNA Methylation Patterns of Glucocorticoid Pathway Genes in Preterm Birth Among Black Women.
- Source :
-
Biological Research for Nursing . Oct2022, Vol. 24 Issue 4, p493-502. 10p. - Publication Year :
- 2022
-
Abstract
- Preterm birth (PTB; <37 weeks gestation) rates have increased for 5 of the last 6 consecutive years in the United States. These rates are particularly alarming for U.S. non-Hispanic Black women who give birth prematurely at 1.5 times the rate of non-Hispanic White women. Previous research suggests that psychological stress is associated with PTB in Black women. However, the biological pathways by which stress alters birth timing are not clear. We examined DNA methylation (DNAm) in peripheral blood leukocytes in 6 glucocorticoid, stress-related genes in 44 (22 PTB; 22 term birth) pregnant Black women. Four cytosine-phosphate-guanine (CpG) sites were identified as differentially methylated (p < 0.05) between women with PTB and women with term births. The ability to identify stress-related biological markers that are associated with PTB among Black women would provide a critical step toward decreasing the PTB disparity among these women. Future studies should include larger sample sizes and gene expression analyses of the stress-related biological pathways to PTB. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GLUCOCORTICOIDS
*PSYCHOLOGY of Black people
*PHYSIOLOGICAL stress
*BIOMARKERS
*PREMATURE infants
*ATTITUDES of mothers
*HETEROCYCLIC compounds
*DURATION of pregnancy
*INFLAMMATION
*METABOLISM
*PREGNANT women
*CASE-control method
*GESTATIONAL age
*DNA methylation
*GENE expression
*HYPOTHALAMIC-pituitary-adrenal axis
*T-test (Statistics)
*PSYCHOLOGY of women
*QUESTIONNAIRES
*DESCRIPTIVE statistics
*CHI-squared test
*RESEARCH funding
*DATA analysis software
*PHOSPHATES
*EPIGENOMICS
*PSYCHOLOGICAL stress
*LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 10998004
- Volume :
- 24
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Biological Research for Nursing
- Publication Type :
- Academic Journal
- Accession number :
- 158934039
- Full Text :
- https://doi.org/10.1177/10998004221099253