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Muscle oxygenation during normoxic and hypoxic cycling exercise in humanswith high-affinity haemoglobin.
- Source :
-
Experimental Physiology . Aug2022, Vol. 107 Issue 8, p854-863. 10p. - Publication Year :
- 2022
-
Abstract
- Recently, researchers in our laboratory have shown that humans with genetic mutations resulting in high-affinity haemoglobin (HAH) demonstrate better maintained aerobic capacity and peak power output during hypoxic exercise versus normoxic exercise in comparison to humans with normal-affinity haemoglobin. However, the influence of HAH on tissue oxygenation within exercising muscle during normoxia and hypoxia is unknown. Therefore, we examined near-infrared spectroscopy-derived oxygenation profiles of the vastus lateralis during graded cycling exercise in normoxia and hypoxia among humans with HAH (n = 5) and control subjects with normal-affinity haemoglobin (n = 12). The HAH group elicited a blunted increase of deoxygenated haemoglobin+myoglobin during hypoxic exercise compared with the control group (P = 0.03), suggesting reduced fractional oxygen extraction in the HAH group. In addition, the HAH group maintained a higher level of muscle tissue oxygen saturation during normoxic exercise (HAH, 75 ± 4% vs. controls, 65 ± 3%, P = 0.049) and there were no differences between groups in muscle tissue oxygen saturation during hypoxic exercise (HAH, 68 ± 3% vs. controls, 68 ± 2%, P = 0.943). Overall, our results suggest that humans with HAH might demonstrate divergent patterns of fractional oxygen extraction during hypoxic exercise and elevated muscle tissue oxygenation during normoxic exercise compared with control subjects. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09580670
- Volume :
- 107
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Experimental Physiology
- Publication Type :
- Academic Journal
- Accession number :
- 158951318
- Full Text :
- https://doi.org/10.1113/EP090308