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Feasibility of outpatient administration of axicabtagene ciloleucel and brexucabtagene autoleucel using telemedicine tools: The Vanderbilt experience.
- Source :
-
British Journal of Haematology . Sep2022, Vol. 198 Issue 6, p1073-1075. 3p. - Publication Year :
- 2022
-
Abstract
- Chimeric antigen receptor T-cell (CAR-T) therapies such as axicabtagene ciloleucel (axi-cel), and brexucabtagene autoleucel (brexu-cel) are approved by the United States Federal Drug Administration for relapsed or refractory large B-cell lymphoma (LBCL), follicular lymphoma and mantle cell lymphoma (MCL).1-5 Given the risk of significant toxicities such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), the registrational trials for axi-cel and brexu-cel required hospitalisation for close monitoring. Patients received lymphodepleting chemotherapy and CAR-T infusion in the outpatient clinic and were subsequently monitored with twice daily in-person visits and one overnight remote visit via telemedicine through day 14 post-infusion. Safety and feasibility of outpatient chimeric antigen receptor (CAR) T-cell therapy: experience from a tertiary care center. [Extracted from the article]
- Subjects :
- *PATIENT selection
*TELEMEDICINE
*CYTOKINE release syndrome
*MANTLE cell lymphoma
Subjects
Details
- Language :
- English
- ISSN :
- 00071048
- Volume :
- 198
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 159025937
- Full Text :
- https://doi.org/10.1111/bjh.18339