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Synergistic effect of glucagon-like peptide-1 analogue liraglutide and ZnO on the antibacterial, hemostatic, and wound healing properties of nanofibrous dressings.
- Source :
-
Journal of Bioscience & Bioengineering . Sep2022, Vol. 134 Issue 3, p248-258. 11p. - Publication Year :
- 2022
-
Abstract
- Bacterial infections and poor vascularization delay wound healing, thus necessitating alternative strategies for functional wound dressings. Zinc oxide (ZnO) has been shown to exert a potent antibacterial effect against bacterial species. Similarly, Glucagon-like peptide-1 (GLP-1) analogue liraglutide (LG) has been shown to promote vascularization and improve wound healing. The objective of this research was to investigate the synergistic effect of ZnO nanoparticles (ZnO-NPs) and LG to simultaneously induce antibacterial, hemostatic, and vascularization effects for infected wound healing. Electrospun poly (l -lactide-co-glycolide)/gelatin (PLGA/Gel) membranes containing ZnO-NPs and LG displayed good biocompatibility and hemostatic ability. Both, ZnO-NPs and LG exhibited synergistic antibacterial effect against Staphylococcus aureus and Escherichia coli as well as improved the migration and tubule-like network formation of human umbilical vein endothelial cells (HUVECs) in vitro. Once evaluated in a bacterial-infected wound model in rats, the membranes loaded with ZnO-NPs and LG effectively promoted wound healing causing significant reduction in wound area and scar-like tissue formation. Therefore, ZnO-NPs/LG synergism may offer an invaluable solution for the treatment of poorly healing infected wounds. [Display omitted] • Bacterial infected diabetic wounds are difficult to be healed, which require alternative solutions for their timely healing. • Functional dressings, which may simultaneously prevent bacterial infection and promote vascularization hold great promise. • Zinc oxide and Liraglutide synergistically improved hemostatic and antibacterial properties as well as the hemocompatibility. • Zinc oxide and Liraglutide containing dressings also promoted wound closure in vitro and in vivo and tube formation in vitro. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13891723
- Volume :
- 134
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Bioscience & Bioengineering
- Publication Type :
- Academic Journal
- Accession number :
- 159031623
- Full Text :
- https://doi.org/10.1016/j.jbiosc.2022.06.004