PHF20L1 mediates PAX2 expression to promote angiogenesis and liver metastasis in colorectal cancer through regulating HIC1.

In conclusion, we found that PHF20L1 upregulated PAX2 to promote malignant cell behaviors and angiogenesis in CRC by inhibiting HIC1, therefore facilitating CRC cell EMT and liver metastasis. Keywords: angiogenesis; colorectal cancer; epithelial-mesenchymal transition (EMT); PHF20L1 EN angiogenesis colorectal cancer epithelial-mesenchymal transition (EMT) PHF20L1 917 928 12 09/13/22 20220901 NES 220901 Introduction Colorectal cancer (CRC) is a common cancer in the digestive system. The 60 pairs of tumor tissues from CRC patients were divided into the PHF20L1-low CRC and PHF20L1-high CRC tissues, and RT-qPCR was used to assess the expression of HIC1 and PAX2. [Extracted from the article]