L-theanine induces skeletal muscle fiber type transformation by activation of prox1/CaN signaling pathway in C2C12 myotubes.

Keywords: C2C12 myotubes; fiber type transformation; L-theanine; prox1/CaN signaling pathway EN C2C12 myotubes fiber type transformation L-theanine prox1/CaN signaling pathway 959 967 9 09/13/22 20220901 NES 220901 Introduction Skeletal muscles comprise approximately 50% of the body weight in most mammals, which is composed of functionally diverse fiber types. These results indicated that LT induced skeletal muscle fiber type transformation was dependent on prox1/CaN signaling pathway. Knockdown of prox1 disrupts LT-induced activation of CaN signaling pathway and muscle fiber t... As shown in Figure 3, LT significantly increased the protein and mRNA level of I prox1 i . [Extracted from the article]