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Taurine can improve intestinal function and integrity in juvenile Rhynchocypris lagowskii Dybowski fed high-dose glycinin.
- Source :
-
Fish & Shellfish Immunology . Oct2022, Vol. 129, p127-136. 10p. - Publication Year :
- 2022
-
Abstract
- The present study evaluated the protective effect and the regulatory mechanism of taurine on growth inhibition and intestinal damage induced by glycinin in juvenile Rhynchocypris lagowskii Dybowski. The control diets had no glycinin and taurine, the glycinin diets contained only 80 g/kg glycinin, and the glycinin + taurine diets contained 80 g/kg glycinin+10 g/kg taurine. Juvenile Rhynchocypris lagowskii Dybowski (4.65 ± 0.03 g/tail) were respectively fed with these 3 diets for 8 weeks. The results showed that glycinin significantly decreased the final body weight, weight gain rate, specific growth rate, protein efficiency rate, feed efficiency rate and feeding rate of fish compared with the control group (P < 0.05). While taurine supplementation improved the growth performance and feed efficiency, but final body weight, weight gain rate, specific growth rate of the glycinin + taurine group were still significantly lower than the control group (P < 0.05). Compared with the glycinin group, taurine supplementation significantly increased whole-body and muscle crude protein content, and hepatopancreas and intestinal protease activities (P < 0.05). Distal intestinal villous dysplasia and mucosal damage, and increased intestinal mucosal permeability were observed in the glycinin group, while taurine supplementation alleviated these adverse effects. Usefully, taurine supplementation could also partially restore the impaired immune function and antioxidant capacity of fish fed glycinin diets. Compared with the glycinin group, taurine supplementation down-regulated pro-inflammatory cytokines TNF‐α and IL-1β mRNA levels, and up-regulated anti-inflammatory cytokines IL-10 and TGF-β mRNA levels. Furthermore, taurine partially reversed the reduction of antioxidant genes Nrf 2、 HO-1 , CAT and GPx mRNA levels in distal intestine induced by glycinin. Concluded, 80 g/kg glycinin led to intestinal damage, digestive dysfunction and increased intestinal mucosal permeability in juvenile Rhynchocypris lagowskii Dybowski, and these adverse effects were ultimately manifested in growth inhibition. But taurine supplementation could partially mitigate the negative effects induced by glycinin. • Taurine supplement could alleviate the growth inhibition induced by glycinin in Rhynchocypris lagowskii Dybowski. • Taurine can effectively enhance serum immunity and alleviate intestinal inflammation caused by high-dose glycinin. • Taurine can alleviate high-dose glycinin-induced oxidative stress in fish through the Nrf2 - Keap1 signaling pathway. • When the Rhynchocypris lagowskii Dybowski diet contains 80 g/kg glycinin, it is recommended to supplement 10 g/kg taurine. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TAURINE
*INTESTINES
*WEIGHT gain
*MUSCLE proteins
*OXIDANT status
Subjects
Details
- Language :
- English
- ISSN :
- 10504648
- Volume :
- 129
- Database :
- Academic Search Index
- Journal :
- Fish & Shellfish Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 159076778
- Full Text :
- https://doi.org/10.1016/j.fsi.2022.08.063