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Iron-Catalyzed Synthesis of Pyrrolo[2,1- a ]isoquinolines via 1,3-Dipolar Cycloaddition/Elimination/Aromatization Cascade and Modifications.
- Source :
-
Synlett . Oct2022, Vol. 33 Issue 16, p1645-1654. 10p. - Publication Year :
- 2022
-
Abstract
- We have developed an iron-catalyzed synthesis of pyrrolo[2,1- a ]isoquinoline derivatives with tetrahydroisoquinolines, arylacyl bromides, and nitroolefins. Highly functionalized pyrrolo[2,1- a ]isoquinolines can be obtained in moderate to good yields through a three-component N-alkylation/oxidative 1,3-dipolar cycloaddition/elimination/aromatization cascade. The obtained products in this study can be easily modified by easy chemical transformations to structurally complex molecules bearing privileged framework. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09365214
- Volume :
- 33
- Issue :
- 16
- Database :
- Academic Search Index
- Journal :
- Synlett
- Publication Type :
- Academic Journal
- Accession number :
- 159194823
- Full Text :
- https://doi.org/10.1055/a-1896-3512