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Atomic resolution Cryo-EM structure of human proteasome activator PA28γ.
- Source :
-
International Journal of Biological Macromolecules . Oct2022, Vol. 219, p500-507. 8p. - Publication Year :
- 2022
-
Abstract
- The PA28 family proteasome activators play important roles in regulating proteasome activities. Though the three paralogs (PA28α, PA28β, and PA28γ) are similar in terms of primary sequence, they show significant differences in expression pattern, cellular localization and most importantly, biological functions. While PA28αβ is responsible for promoting peptidase activity of proteasome to facilitate MHC-I antigen processing, but unable to promote protein degradation, PA28γ is well-known to not only promote peptidase activity but also proteolytic activity of proteasome. However, why this paralog has the unique function remains elusive. Previous structural studies have mainly focused on mammalian PA28α, PA28β and PA28αβ heptamers, while structural studies on mammalian PA28γ of atomic resolution are still absent to date. In the present work, we determined the Cryo-EM structure of the human PA28γ heptamer at atomic resolution, revealing interesting unique structural features that may hint our understanding the functional mechanisms of this proteasome activator. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PROTEASOMES
*PROTEOLYSIS
*ANTIGEN processing
*PEPTIDASE
*HUMAN beings
Subjects
Details
- Language :
- English
- ISSN :
- 01418130
- Volume :
- 219
- Database :
- Academic Search Index
- Journal :
- International Journal of Biological Macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 159290432
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2022.07.246