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Syndecan-4 is More Sensitive in Detecting Hypertensive Left Ventricular Diastolic Dysfunction in 2K2C Rats.
- Source :
-
International Journal of Hypertension . 9/24/2022, p1-8. 8p. - Publication Year :
- 2022
-
Abstract
- Objective. The aim of this study was to investigate the changes of syndecan-4 (SDC-4) during the hypertensive period in two kidney-two clip (2K2C) hypertension rats and compare them to brain natriuretic peptide (BNP) and the echocardiographic parameters for diastolic function evaluation in the rat model of 2K2C hypertension. Methods. A total of 36 Sprague–Dawley (SD) rats were used in this study. Hypertension was induced in 21 by 2K2C surgery, and 15 were sham-operated. Both the 2K2C hypertension group (n = 21) and the sham-operated group (n = 15) were equally divided into 3 subgroups according to the schedules (week 4, week 8, and week 12). Serum SDC-4 and BNP were detected by ELISA, and echocardiography indexes were acquired. Results. The level of SDC-4 and cardiac fibrosis increased gradually as the experiment was processed, and BNP, Tei index, and E/E′ followed to be raised as high blood pressure was maintained after four weeks in the 2K2C hypertension rats. In the earlier 4 weeks, only SDC-4 and cardiac fibrosis were significantly increased in 2K2C hypertensive rats in comparison with normotensive rats. And it was shown that SDC-4 was positively correlated with BNP level during the entire study (r = 0.762, p < 0.01). Conclusion. SDC-4 increases gradually during the process of diastolic dysfunction in 2K2C hypertensive rats. SDC-4 is the earliest biomarker reflecting diastolic dysfunction in this model, superior to E/E′ and the Tei index. Our results indicate that serum SDC-4 could act as an early biomarker to show diastolic dysfunction. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYPERTENSION
*EXPERIMENTAL design
*STATISTICAL significance
*ECHOCARDIOGRAPHY
*BIOMARKERS
*LEFT ventricular dysfunction
*ANIMAL experimentation
*REGRESSION analysis
*RATS
*T-test (Statistics)
*PEARSON correlation (Statistics)
*GLYCOPROTEINS
*HISTOLOGICAL techniques
*DESCRIPTIVE statistics
*ENZYME-linked immunosorbent assay
*PEPTIDE hormones
*SENSITIVITY & specificity (Statistics)
*DATA analysis software
*STATISTICAL correlation
*DISEASE complications
*EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 20900384
- Database :
- Academic Search Index
- Journal :
- International Journal of Hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 159291343
- Full Text :
- https://doi.org/10.1155/2022/1447425