Genome-Wide Identification of P450 Genes in Chironomid Propsilocerus akamusi Reveals Candidate Genes Involved in Gut Microbiota-Mediated Detoxification of Chlorpyrifos.

We then established a gut microbiota-deficient model of I P. akamusi i with the support of antibiotics for the first time and attempted to reveal a possible interaction between bacterial colonizers and the regulation of detoxification-associated genes, particularly P450s, in gut tissues of larvae treated with both a lethal and a sublethal dosage of CPF. Keywords: Propsilocerus akamusi; P450 gene; gut microbiota deficient; chlorpyrifos; regulation EN Propsilocerus akamusi P450 gene gut microbiota deficient chlorpyrifos regulation N.PAG N.PAG 17 09/27/22 20220901 NES 220901 1. 10.1002/ps.4879 6 Jing T.X., Wang D.F., Ma Y.P., Zeng L.L., Meng L.W., Zhang Q., Dou W., Wang J.J. Genome-wide and expression-profiling analyses of the cytochrome P450 genes in Bactrocera dorsalis (Hendel) and screening of candidate P450 genes associated with malathion resistance. Thus, gut microbiota of chironomid larvae could be considered as a modifier for CPF-mediated regulation of P450s in digestive tracts and the altered pattern is relevant to the concentration of invading CPF. [Extracted from the article]