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Efficient Construction of Tetracyclic 1,2,4‐Triazoline‐Fused Dibenzo[b,f][1,4]oxazepines through KI/TBHP‐Mediated [3+2] Annulation between DBO‐Imines and N‐Tosylhydrazones.
- Source :
-
European Journal of Organic Chemistry . 9/20/2022, Vol. 2022 Issue 35, p1-5. 5p. - Publication Year :
- 2022
-
Abstract
- The KI/TBHP (tert‐butyl hydroperoxide) promoted [3+2] annulation between dibenzo[b,f][1,4]oxazepine‐imines (DBO‐Imines) and N‐tosylhydrazones under mild conditions has been developed, affording a direct and high atom‐economical preparation for tetracyclic 1,2,4‐triazoline‐fused dibenzo[b,f][1,4]oxazepines (DBOs) in good to excellent yields. This procedure could tolerate a wide range of functional groups and could also be conveniently conducted on a gram‐scale reaction, even in a one‐pot fashion. The produced 1,2,4‐triazoline‐fused DBOs could be easily converted into biologically interesting 1,2,4‐triazolo‐fused DBOs under the action of NBS (N‐bromosuccinimide). [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYDROPEROXIDES
*ANNULATION
*FUNCTIONAL groups
Subjects
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2022
- Issue :
- 35
- Database :
- Academic Search Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 159361642
- Full Text :
- https://doi.org/10.1002/ejoc.202200888