A STUDY ON THE EFFECT OF DIABETES MELLITUS ON CENTRAL CORNEAL THICKNESS AND INTRAOCULAR PRESSURE IN PATIENTS ATTENDING A TERTIARY CARE HOSPITAL IN KOLKATA, INDIA.

Introduction: Diabetic patients had been proved to have thicker corneas and are commonly associated with primary open-angle glaucoma. Diabetic people have two times increased chance of developing glaucoma compared with non-diabetics. Objective: To compare the central corneal thickness of type II Diabetes Mellitus patients with age and gender matched healthy subjects and relation of central corneal thickness and intraocular pressure in diabetic type II patients. Materials and method: This Institution based cross sectional comparative study was conducted in Regional Institute of Ophthalmology, Medical College and Hospital, Kolkata. The study period was One and a half year (1 January, 2018 to 30th June, 2019). Four hundred (400) eyes were included in this study. Result: We found that, most of the patients were 51-60 years old and age was significantly associated with both groups. male population was higher than the female population. Sex was not significantly related with both groups. Present study showed that, majority number of patients had Normal fundus in Non-Diabetic Group compared to No DR in Diabetic Group though it was statistically significant. We found that, FBS was significantly higher in Diabetic Group compared to Non-Diabetic Group and we observed that, PPBS was higher in Diabetic Group compared to Non-Diabetic Group. It was found that, HbA1c significantly higher Diabetic Group compared to Non-Diabetic Group. We observed that, CCT was significantly lower in Non-Diabetic Group compared to Diabetic Group. In our study, IOP was slightly higher in Diabetic Group compared to Non-Diabetic Group which was not statistically significant and our study showed that, CCT vs IOP was significantly positive correlation and CCT vs IOP but this was not statistically significant. Conclusion: Type 2 DM patients were found to have significantly thicker cornea n their IOP was found to be higher than no diabetic control. There is a strong positive correlation between CCT and IOP of patients included in our study with Pearson correlation coefficient being .093. [ABSTRACT FROM AUTHOR]