CRYOGLOBULINS IN ACUTE AND CHRONIC LIVER DISEASES.

Cryoglobulin's were detected in the sera of thirteen patients with acute viral hepatitis and of twelve with chronic hepatic diseases tactic chronic hepatitis, primary biliary cirrhosis and cryptogentice cirrhosis). Their nature and antibody activity was studied, In both groups, most of them consisted of mixed cryoimmunoglobulins (Igg and/ire UA) but some were single-class immunoglobulins with one or both types of light chains, Unusual components were also found. fetoprotein was present in four cryoprecipitate's in two as the single constituent and in two associated to immunoglobulins: hepatititsassociated antigen co-existed in one of the latter, some sryoglobulins showed antibody activity against human IgG. smooth mus ele and mitochondrial antigens, In one case. the IgM-Kappa of the cryoprecipitate had antibody against fetoprotein this antigen was also present tin the cryoprecipitate, suggesting immune complex formation. An Autoantibodies were aksi kicked fir bub tee sera if tee tweet fume oatuebts apart frin tee nits cinnib ibesm abtuvidues 10 fetoprotein were found in two patients. [ABSTRACT FROM AUTHOR]