THE EFFECT OF ANTILYMPHOCYTIC ANTIBODY ON THE HUMORAL IMMUNE RESPONSE OF DIFFERENT STRAINS OF MICE.

Antilymphocytic globulin (ALG) depressed the antibody responses of mice to SRBC as measured in terms of splenic PFCs of IgM, IgG1, IgG2a and IgG2b specificity. This effect was apparent over a range of antigen does. ALG also reduced the antibody responses of congenitally athymic mice to SRBC and SHI. The possible mode of action of ALG is discussed in the light of these, and other, observations. [ABSTRACT FROM AUTHOR]