Preparation and in vivo imaging of a novel potential αvβ3 targeting PET/MRI dual-modal imaging agent.

Multi-modal biomedical imaging has played an essential role in tumor diagnosis. However, constructing a multi-modal imaging contrast agent with high affinity to a tumor is challenging. Herein, we studied the design and application of a PET/MRI dual-modal imaging agent based on superparamagnetic iron oxide nanoparticles (SPION). αvβ3-targeting RGD peptide and 64Cu were conjugated onto SPION. Small animal PET and MR imaging in glioblastoma tumor-bearing mice revealed that this dual-modal imaging contrast agent could potentially be utilized for PET/MRI dual-modal imaging for the tumor diagnosis. [ABSTRACT FROM AUTHOR]