Effect of carob bean on gastric emptying time in Thai infants.

Thickening agents, such as carob bean gum or galactomannan, have been successfully administered for the treatment of gastro esophageal reflux in infants. To study the effect of carob bean gum on gastric emptying and to symptoms of regurgitation, we recruited 20 full term Thai infants (mean age 13.4 ± 7 week; mean body weight = 4943 ± 1272gm) without pathological gastroesophageal reflux. Initially, we determined halftime gastric emptying (T 1/2 GET) by Tc99m radioscintigraphy method (mean T 1/2 GET = 116.1 ±72 mm) in infants consuming standard infant cow's milk formula for 2 weeks. Afterwards, carob bean infant formula was given for 2-4 weeks and weight gain, vomiting symptoms, night cough, colic, flatus, defaecation character and T 1/2 GET were assessed. There were statistically significant improvements in symptoms of vomiting (a smaller quantity P<0.00l and frequency of vomiting P < 0.0001) and improvements in weight gain per week (W1 = 121.2 + 106.9gm, W2 221.3 + 136.1gm; P = 0.005) when infants consumed the carob bean formula. However, there was no significance difference in gastric emptying half time (GET1 = 116.1 + 72, GET2 = 148.5 + 130.9; P= 0.154). In conclusion, carob bean gum, as a thickening agent, improves the clinical symptoms of regurgitating infants, but does not significantly alter the gastric emptying physiology. [ABSTRACT FROM AUTHOR]