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A roadmap for a comprehensive diagnostic approach to fine needle cytology of lymph node metastases.
- Source :
-
Cytopathology . Nov2022, Vol. 33 Issue 6, p668-677. 10p. - Publication Year :
- 2022
-
Abstract
- Objective: Fine needle cytology (FNC) is widely used as a first‐line procedure in the diagnostic algorithm of lymphadenopathies. In a metastatic setting, a first‐line diagnostic approach identifies non‐haematopoietic malignancy; however, cytopathologists could also provide a second diagnostic level, identifying the origin of the primary tumour. This paper outlines a comprehensive and practical approach to the cytological diagnosis of lymph node metastases. Methods: Cytological diagnoses of lymph node metastases performed over a 10‐year period were selected and divided into two groups. The first group, labelled "oncological," comprised patients with a previous history of malignancy; the second group, labelled "naïve," included patients with no relevant history. Pathology records were retrieved to record microscopic findings, namely, background appearance, group architecture, and specific cell features; data from cell block (CB) preparations were also collected. Results: Overall, 982 cases were selected: 497 cases (50.61%) in the naïve group, and 485 (49.39%) in the oncological group. Overall, a second diagnostic level was achieved in 834/982 cases (84.92%); cases diagnosed as carcinoma not otherwise specified were more frequent in the naïve group than in the oncological group (17.51% vs. 8.04%, P < 0.01). Notably, although CB material was available in only 44.87% of the naïve cases, we were able to achieve a second diagnostic level thanks to the integration of clinical and cytomorphological findings, plus lymph node topography, in 82.49% of the cases. Conclusion: Our results confirmed that in a metastatic setting, FNC can reliably lead to the identification of the origin of the primary tumour. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LYMPHATIC metastasis
*CYTOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 09565507
- Volume :
- 33
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Cytopathology
- Publication Type :
- Academic Journal
- Accession number :
- 159615008
- Full Text :
- https://doi.org/10.1111/cyt.13172